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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDOzone results in increased expression of BAX proteinPMID:23988432
Baxmultiple interactionsEXP 6480464CTD[Ozone co-treated with Chlorine] results in decreased expression of BAX mRNAPMID:18636392
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDOzone results in decreased expression of BAX mRNAPMID:27842206
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of BAX mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of BAX mRNA; [Volatile Organic Compounds co-treated with Ozone] results in increased oxidation of BAX mRNA; Ozone inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA]PMID:27842206 PMID:32699268
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