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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1354508
Species: Homo sapiens
RGD Object: Gene
Symbol: CSF2
Name: colony stimulating factor 2
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CSF2increases expressionEXP 6480464CTDOzone results in increased expression of CSF2 mRNAPMID:31476115
CSF2multiple interactionsEXP 6480464CTD[Aripiprazole co-treated with Ozone] results in increased expression of CSF2 mRNAPMID:31476115
CSF2decreases expressionISOCsf2 (Rattus norvegicus)6480464CTDOzone results in decreased expression of CSF2 mRNAPMID:16330353
CSF2increases expressionISOCsf2 (Mus musculus)6480464CTDOzone results in increased expression of CSF2 mRNA; Ozone results in increased expression of CSF2 proteinPMID:18315731 PMID:26752192
CSF2multiple interactionsISOCsf2 (Mus musculus)6480464CTD3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester inhibits the reaction [Ozone results in increased expression of CSF2 protein]; Ozone results in increased expression of and results in increased secretion of CSF2 proteinPMID:26752192
CSF2multiple interactionsISOCsf2 (Rattus norvegicus)6480464CTDOzone promotes the reaction [[CSF2 protein results in increased expression of ITGB2 protein] which results in increased abundance of Nitric Oxide]PMID:8600936
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