Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1345394
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	LTA
Name:	lymphotoxin alpha

Acc ID:	CHEBI:25812
Term:	ozone
Definition:	An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID:	MESH:D010126

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
LTA	multiple interactions	EXP		6480464	CTD	[Aripiprazole co-treated with Ozone] results in increased expression of LTA mRNA	PMID:31476115
LTA	decreases expression	ISO	Lta (Mus musculus)	6480464	CTD	Ozone results in decreased expression of LTA mRNA	PMID:26342085
LTA	decreases response to substance	ISO	Lta (Mus musculus)	6480464	CTD	LTA gene mutant form results in decreased susceptibility to Ozone	PMID:20032013
LTA	increases expression	ISO	Lta (Mus musculus)	6480464	CTD	Ozone results in increased expression of LTA mRNA	PMID:20032013
LTA	multiple interactions	ISO	Lta (Mus musculus)	6480464	CTD	[[LTA gene mutant form co-treated with TNF gene mutant form co-treated with LTB gene mutant form] co-treated with Ozone] results in decreased expression of H2-EB1 mRNA; [H2-AB1 gene mutant form co-treated with H2-AA gene mutant form co-treated with H2-EB1 gene mutant form co-treated with H2-EB2 gene mutant form co-treated with H2-EA gene mutant form] inhibits the reaction [Ozone results in increased expression of LTA mRNA]; [LTA gene mutant form co-treated with Ozone] results in decreased expression of H2-EB1 mRNA; [LTA gene mutant form co-treated with TNF gene mutant form co-treated with LTB gene mutant form] inhibits the reaction [Ozone results in increased expression of H2-EB2 mRNA]; [LTA gene mutant form co-treated with TNF gene mutant form co-treated with LTB gene mutant form] results in decreased susceptibility to Ozone; LTA gene mutant form inhibits the reaction [Ozone results in increased expression of H2-EB2 mRNA]	PMID:20032013

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