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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305489
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acss2
Name: acyl-CoA synthetase short-chain family member 2
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acss2increases expressionISOAcss2 (Mus musculus)6480464CTDOzone results in increased expression of ACSS2 mRNAPMID:33026818
Acss2multiple interactionsISOACSS2 (Homo sapiens)6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of ACSS2 mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of and results in increased oxidation of ACSS2 mRNA; [Air Pollutants results in increased abundance of Ozone] which affects the expression of ACSS2 mRNA; [Volatile Organic Compounds co-treated with Ozone] results in decreased expression of and results in increased oxidation of ACSS2 mRNAPMID:32699268 PMID:35430440
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