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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10331
Species: Mus musculus
RGD Object: Gene
Symbol: Cftr
Name: cystic fibrosis transmembrane conductance regulator
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cftrmultiple interactionsEXP 6480464CTD[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of CFTR mRNAPMID:34911549
Cftrdecreases expressionISOCFTR (Homo sapiens)6480464CTDOzone results in decreased expression of CFTR mRNA; Ozone results in decreased expression of CFTR proteinPMID:19061877
Cftrincreases expressionISOCFTR (Homo sapiens)6480464CTDOzone results in increased expression of CFTR mRNAPMID:27206323
Cftrmultiple interactionsISOCFTR (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Ozone results in decreased expression of CFTR mRNA]; Acetylcysteine inhibits the reaction [Ozone results in decreased expression of CFTR protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Ozone results in decreased expression of CFTR mRNA]; Ozone inhibits the reaction [Colforsin results in increased activity of CFTR protein]; pimagedine inhibits the reaction [Ozone results in decreased expression of CFTR mRNA]; pimagedine inhibits the reaction [Ozone results in decreased expression of CFTR protein]PMID:19061877
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