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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619996
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bche
Name: butyrylcholinesterase
Acc ID: CHEBI:25710
Term: organophosphorus compound
Definition: An organophosphorus compound is formally a compound containing at least one carbon-phosphorus bond, but the term is often extended to include esters and thioesters.
Chemical ID: MESH:D009943
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcheaffects bindingISOBCHE (Homo sapiens)6480464CTDOrganophosphorus Compounds metabolite binds to BCHE proteinPMID:22989774
Bcheaffects response to substanceISOBCHE (Homo sapiens)6480464CTDBCHE protein affects the susceptibility to Organophosphorus CompoundsPMID:17955620
Bchedecreases activityISOBCHE (Homo sapiens)6480464CTDOrganophosphorus Compounds results in decreased activity of BCHE proteinPMID:16824336 PMID:17955620 PMID:2432808 PMID:26340881
Bchedecreases activityISOBche (Mus musculus)6480464CTDOrganophosphorus Compounds results in decreased activity of BCHE proteinPMID:27154493
Bcheincreases hydrolysisISOBCHE (Homo sapiens)6480464CTDBCHE protein mutant form results in increased hydrolysis of Organophosphorus CompoundsPMID:18508040
Bcheincreases metabolic processingISOBCHE (Homo sapiens)6480464CTDBCHE protein results in increased metabolism of Organophosphorus CompoundsPMID:22209767
Bcheincreases metabolic processingISOBche (Mus musculus)6480464CTDBCHE protein results in increased metabolism of Organophosphorus CompoundsPMID:22209767
Bcheincreases response to substanceISOBCHE (Homo sapiens)6480464CTDBCHE gene polymorphism results in increased susceptibility to Organophosphorus CompoundsPMID:17955620
Bchemultiple interactionsISOBCHE (Homo sapiens)6480464CTDOrganophosphorus Compounds inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]PMID:12190811 PMID:2432808
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