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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348437
Species: Homo sapiens
RGD Object: Gene
Symbol: MMP9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:254496
Term: 7,12-dimethyltetraphene
Definition: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
Chemical ID: MESH:D015127
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MMP9affects expressionISOMmp9 (Mus musculus)6480464CTD9,10-Dimethyl-1,2-benzanthracene affects the expression of MMP9 mRNAPMID:21785161
MMP9increases expressionISOMmp9 (Rattus norvegicus)6480464CTD9,10-Dimethyl-1,2-benzanthracene results in increased expression of MMP9 proteinPMID:12208745 PMID:34896434
MMP9multiple interactionsISOMmp9 (Rattus norvegicus)6480464CTD[9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of MMP9 protein; [9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride] affects the expression of MMP9 protein; [Ruthenium binds to Phloretin] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MMP9 protein]; Resveratrol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MMP9 protein]PMID:12208745 PMID:31332895 PMID:34896434
MMP9multiple interactionsISOMmp9 (Mus musculus)6480464CTD[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of and results in increased activity of MMP9 protein; [9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of MMP9 mRNA; [sodium arsenite results in increased susceptibility to [9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate]] which results in increased expression of MMP9 protein; Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of and results in increased activity of MMP9 protein]; Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of MMP9 mRNA]; Cisplatin promotes the reaction [NPPC protein inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of and results in increased activity of MMP9 protein]]; Cisplatin promotes the reaction [NPPC protein inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of MMP9 mRNA]]; NPPC protein inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of and results in increased activity of MMP9 protein]; NPPC protein inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of MMP9 mRNA]; NPPC protein promotes the reaction [Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of and results in increased activity of MMP9 protein]]; NPPC protein promotes the reaction [Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of MMP9 mRNA]]PMID:35364107 PMID:37352108
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