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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69095
Species: Homo sapiens
RGD Object: Gene
Symbol: TGFB1
Name: transforming growth factor beta 1
Acc ID: CHEBI:25434
Term: bis(2-chloroethyl) sulfide
Definition: An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention.
Chemical ID: MESH:D009151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TGFB1increases expressionEXP 6480464CTDMustard Gas results in increased expression of TGFB1 proteinPMID:15286001 PMID:17266442
TGFB1increases secretionISOTgfb1 (Rattus norvegicus)6480464CTDMustard Gas results in increased secretion of TGFB1 proteinPMID:27605419
TGFB1multiple interactionsISOTgfb1 (Rattus norvegicus)6480464CTDAEOL 10150 inhibits the reaction [Mustard Gas results in increased secretion of TGFB1 protein]PMID:27605419
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