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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620545
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chek1
Name: checkpoint kinase 1
Acc ID: CHEBI:25434
Term: bis(2-chloroethyl) sulfide
Definition: An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention.
Chemical ID: MESH:D009151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chek1decreases expressionISOCHEK1 (Homo sapiens)6480464CTDMustard Gas results in decreased expression of CHEK1 mRNAPMID:33491125
Chek1increases phosphorylationISOCHEK1 (Homo sapiens)6480464CTDMustard Gas results in increased phosphorylation of CHEK1 proteinPMID:22119920 PMID:25448276
Chek1multiple interactionsISOCHEK1 (Homo sapiens)6480464CTD2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein]; 4-(4-(3-methylmorpholin-4-yl)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-2-yl)-1H-indole inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein]; PF 00477736 inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein]; wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein]PMID:22119920 PMID:25448276
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