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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345118
Species: Homo sapiens
RGD Object: Gene
Symbol: PARP1
Name: poly(ADP-ribose) polymerase 1
Acc ID: CHEBI:25434
Term: bis(2-chloroethyl) sulfide
Definition: An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention.
Chemical ID: MESH:D009151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PARP1decreases expressionEXP 6480464CTDMustard Gas results in decreased expression of PARP1 mRNAPMID:25102026
PARP1increases cleavageEXP 6480464CTDMustard Gas results in increased cleavage of PARP1 proteinPMID:11886524 PMID:12482751 PMID:17229443 PMID:20435105 PMID:25448276
PARP1multiple interactionsEXP 6480464CTDacetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Mustard Gas results in increased cleavage of PARP1 protein]; BRCA2 protein inhibits the reaction [Mustard Gas results in increased cleavage of PARP1 protein]; CALM1 protein promotes the reaction [Mustard Gas results in increased cleavage of and results in increased activity of PARP1 protein]; FADD protein affects the reaction [Mustard Gas results in increased cleavage of PARP1 protein]; Mustard Gas promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]; Mustard Gas results in increased cleavage of and results in increased activity of PARP1 protein; PARP1 protein affects the reaction [Mustard Gas affects the activity of CASP3 protein]; pifithrin promotes the reaction [Mustard Gas results in increased cleavage of PARP1 protein]PMID:11886524 PMID:12482751 PMID:16935404 PMID:20435105 PMID:25448276
PARP1increases cleavageISOParp1 (Rattus norvegicus)6480464CTDMustard Gas results in increased cleavage of PARP1 proteinPMID:20659490
PARP1multiple interactionsISOParp1 (Mus musculus)6480464CTDPARP1 protein inhibits the reaction [Mustard Gas results in increased activity of CASP3 protein]PMID:11886524
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