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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:2524
Term: ajmalicine
Definition: A monoterpenoid indole alkaloid with formula C21H24N2O3, isolated from several Rauvolfia and Catharanthus species. It is a selective alpha1-adrenoceptor antagonist used for the treatment of high blood pressure.
Chemical ID: MESH:C005709
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:7362176480464CTDraubasine results in decreased activity of CYP2D6 protein

PMID:15930738
multiple interactionsISORGD:7362176480464CTDraubasine inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]

PMID:15930738
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.