GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfe2l2 | multiple interactions | EXP | | 6480464 | CTD | [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFE2L2 protein; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 protein; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 protein] | PMID:27837179 PMID:37415728 | Nfe2l2 | increases activity | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | Mercury results in increased activity of NFE2L2 promoter | PMID:21643505 | Nfe2l2 | increases expression | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Mercury results in increased expression of NFE2L2 mRNA | PMID:16243960 | Nfe2l2 | multiple interactions | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | [Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of NFE2L2 protein | PMID:30359721 | Nfe2l2 | multiple interactions | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | NFE2L2 protein affects the reaction [Mercury results in increased expression of GSTA1 mRNA]; NFE2L2 protein affects the reaction [Mercury results in increased expression of NQO1 mRNA] | PMID:16243960 | | ||||||||||||||||||||||
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