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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:25195
Term: mercury atom
Definition: A zinc group element atom that has formula Hg.
Chemical ID: MESH:D008628
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDMercury results in increased expression of IL1B mRNA; Mercury results in increased expression of IL1B proteinPMID:25237059 PMID:37137463
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTDMercury results in increased expression of IL1B proteinPMID:20176347
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTD[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL1B mRNA; N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercury results in increased expression of IL1B mRNA]PMID:25237059 PMID:28453771
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTDMercury promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]PMID:20600710
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