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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:25195
Term: mercury atom
Definition: A zinc group element atom that has formula Hg.
Chemical ID: MESH:D008628
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDMercury results in increased expression of HMOX1 mRNA

PMID:12730625
increases expressionISORGD:107176480464CTDMercury results in increased expression of HMOX1 mRNA

PMID:15297030, PMID:16093525, PMID:18078826, PMID:22579925, PMID:23231920
increases expressionISORGD:7309016480464CTDMercury results in increased expression of HMOX1 mRNA

PMID:17244614, PMID:17547211
multiple interactionsISORGD:107176480464CTD[Benzo(a)pyrene co-treated with Mercury] results in increased expression of HMOX1 mRNA, [beta-Naphthoflavone co-treated with Mercury] results in increased expression of HMOX1 mRNA, [Methylcholanthrene co-treated with Mercury] results in increased expression of HMOX1 mRNA, [Tetrachlorodibenzodioxin co-treated with Mercury] results in increased expression of HMOX1 mRNA, Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of HMOX1 protein], Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of HMOX1 mRNA], Mercury results in increased expression of and results in increased activity of HMOX1 protein, pyrazolanthrone inhibits the reaction [Mercury results in increased expression of HMOX1 mRNA], pyrrolidine dithiocarbamic acid promotes the reaction [Mercury results in increased expression of HMOX1 mRNA], SB 203580 inhibits the reaction [Mercury results in increased expression of HMOX mRNA], Tetrachlorodibenzodioxin promotes the reaction [Mercury results in increased expression of HMOX1 mRNA], Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of HMOX1 mRNA], U 0126 promotes the reaction [Mercury results in increased expression of HMOX1 mRNA]

PMID:15297030, PMID:18078826, PMID:22579925, PMID:23231920
multiple interactionsISORGD:7309016480464CTDMercury promotes the reaction [HSF1 protein binds to HMOX1 promoter]

PMID:17244614
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.