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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735784
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL3
Name: C-C motif chemokine ligand 3
Acc ID: CHEBI:25051
Term: lipid As
Definition: Glycophospholipids that are the components of endotoxins held responsible for the toxicity of Gram-negative bacteria. Lipid A is the innermost of the three regions of the lipopolysaccharide (LPS) molecule, and its hydrophobic nature allows it to anchor the LPS to the outer membrane. Four acyl chains attached directly to two (1->6)-linked glucosamine sugars are beta-hydroxy acyl chains usually between 10 and 16 carbons in length. Two additional acyl chains are often attached to the beta-hydroxy group.
Chemical ID: MESH:D008050
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCL3increases expressionISOCcl3 (Mus musculus)6480464CTDLipid A results in increased expression of CCL3 mRNAPMID:20448206
CCL3multiple interactionsISOCcl3 (Mus musculus)6480464CTDanacetrapib inhibits the reaction [Lipid A results in increased expression of CCL3 mRNA]PMID:20448206
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