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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735753
Species: Mus musculus
RGD Object: Gene
Symbol: Runx2
Name: runt related transcription factor 2
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Runx2decreases methylationISORUNX2 (Homo sapiens)6480464CTDAflatoxin B1 results in decreased methylation of RUNX2 genePMID:27153756
Runx2increases expressionISORUNX2 (Homo sapiens)6480464CTDAflatoxin B1 results in increased expression of RUNX2 mRNAPMID:32234424
Runx2increases methylationISORUNX2 (Homo sapiens)6480464CTDAflatoxin B1 results in increased methylation of RUNX2 intronPMID:30157460
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