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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730835
Species: Mus musculus
RGD Object: Gene
Symbol: Akr1b7
Name: aldo-keto reductase family 1, member B7
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1b7decreases expressionEXP 6480464CTDAflatoxin B1 results in decreased expression of AKR1B7 mRNA

PMID:19770486
Akr1b7increases expressionISORGD:6202576480464CTDAflatoxin B1 results in increased expression of AKR1B7 mRNA

PMID:23630614, PMID:25378103
Akr1b7increases methylationISORGD:35166546480464CTDAflatoxin B1 results in increased methylation of AKR1B15 gene

PMID:27153756
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.