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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730822
Species: Mus musculus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDAflatoxin B1 results in decreased expression of MMP2 proteinPMID:34396909
Mmp2decreases methylationISOMMP2 (Homo sapiens)6480464CTDAflatoxin B1 results in decreased methylation of MMP2 exonPMID:30157460
Mmp2increases expressionISOMmp2 (Rattus norvegicus)6480464CTDAflatoxin B1 results in increased expression of MMP2 mRNAPMID:23630614 PMID:33354967
Mmp2increases expressionISOMMP2 (Homo sapiens)6480464CTDAflatoxin B1 results in increased expression of MMP2 mRNAPMID:32234424
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