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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68500
Species: Mus musculus
RGD Object: Gene
Symbol: Nr5a2
Name: nuclear receptor subfamily 5, group A, member 2
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr5a2affects expressionISONR5A2 (Homo sapiens)6480464CTDAflatoxin B1 affects the expression of NR5A2 proteinPMID:20106945
Nr5a2decreases methylationISONR5A2 (Homo sapiens)6480464CTDAflatoxin B1 results in decreased methylation of NR5A2 genePMID:27153756
Nr5a2increases methylationISONR5A2 (Homo sapiens)6480464CTDAflatoxin B1 results in increased methylation of NR5A2 intronPMID:30157460
Nr5a2multiple interactionsISONr5a2 (Rattus norvegicus)6480464CTD[sulforaphane co-treated with Aflatoxin B1] affects the expression of NR5A2 mRNAPMID:25450479
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