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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62221
Species: Mus musculus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1, alpha subunit
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1aaffects expressionISOHIF1A (Homo sapiens)6480464CTDAflatoxin B1 affects the expression of HIF1A proteinPMID:20106945
Hif1aincreases expressionISOHIF1A (Homo sapiens)6480464CTDAflatoxin B1 results in increased expression of HIF1A mRNAPMID:27153756
Hif1amultiple interactionsISOHif1a (Rattus norvegicus)6480464CTD[Aflatoxin B1 co-treated with Ethanol] results in increased expression of HIF1A protein; Sildenafil Citrate inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of HIF1A protein]; Tadalafil inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of HIF1A protein]PMID:35608386
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