Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62089
Species: Mus musculus
RGD Object: Gene
Symbol: Prkn
Name: parkin RBR E3 ubiquitin protein ligase
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prknincreases expressionEXP 6480464CTDAflatoxin B1 results in increased expression of PRKN mRNA; Aflatoxin B1 results in increased expression of PRKN proteinPMID:35304092
Prknmultiple interactionsEXP 6480464CTDPRKN protein affects the reaction [Aflatoxin B1 results in decreased expression of BCL2 protein]; PRKN protein affects the reaction [Aflatoxin B1 results in decreased expression of SQSTM1 mRNA]; PRKN protein affects the reaction [Aflatoxin B1 results in decreased expression of SQSTM1 protein]; PRKN protein affects the reaction [Aflatoxin B1 results in increased activity of CASP3 protein]; PRKN protein affects the reaction [Aflatoxin B1 results in increased expression of BAX protein]; PRKN protein affects the reaction [Aflatoxin B1 results in increased expression of MAP1LC3B mRNA]; PRKN protein affects the reaction [Aflatoxin B1 results in increased expression of PINK1 mRNA]; PRKN protein affects the reaction [Aflatoxin B1 results in increased expression of PINK1 protein]PMID:35304092
Prknaffects methylationISOPRKN (Homo sapiens)6480464CTDAflatoxin B1 affects the methylation of PRKN intronPMID:30157460
Prkndecreases expressionISOPRKN (Homo sapiens)6480464CTDAflatoxin B1 results in decreased expression of PARK2 mRNA; Aflatoxin B1 results in decreased expression of PRKN mRNAPMID:31555880 PMID:32234424 PMID:35690182
Prkndecreases methylationISOPRKN (Homo sapiens)6480464CTDAflatoxin B1 results in decreased methylation of PRKN genePMID:27153756
Go Back to source page   Continue to Ontology report