GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Prkn | increases expression | EXP | | 6480464 | CTD | Aflatoxin B1 results in increased expression of PRKN mRNA; Aflatoxin B1 results in increased expression of PRKN protein | PMID:35304092 | Prkn | multiple interactions | EXP | | 6480464 | CTD | PRKN protein affects the reaction [Aflatoxin B1 results in decreased expression of BCL2 protein]; PRKN protein affects the reaction [Aflatoxin B1 results in decreased expression of SQSTM1 mRNA]; PRKN protein affects the reaction [Aflatoxin B1 results in decreased expression of SQSTM1 protein]; PRKN protein affects the reaction [Aflatoxin B1 results in increased activity of CASP3 protein]; PRKN protein affects the reaction [Aflatoxin B1 results in increased expression of BAX protein]; PRKN protein affects the reaction [Aflatoxin B1 results in increased expression of MAP1LC3B mRNA]; PRKN protein affects the reaction [Aflatoxin B1 results in increased expression of PINK1 mRNA]; PRKN protein affects the reaction [Aflatoxin B1 results in increased expression of PINK1 protein] | PMID:35304092 | Prkn | affects methylation | ISO | PRKN (Homo sapiens) | 6480464 | CTD | Aflatoxin B1 affects the methylation of PRKN intron | PMID:30157460 | Prkn | decreases expression | ISO | PRKN (Homo sapiens) | 6480464 | CTD | Aflatoxin B1 results in decreased expression of PARK2 mRNA; Aflatoxin B1 results in decreased expression of PRKN mRNA | PMID:31555880 PMID:32234424 PMID:35690182 | Prkn | decreases methylation | ISO | PRKN (Homo sapiens) | 6480464 | CTD | Aflatoxin B1 results in decreased methylation of PRKN gene | PMID:27153756 | |
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