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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620715
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnma1
Name: potassium calcium-activated channel subfamily M alpha 1
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnma1affects methylationISOKCNMA1 (Homo sapiens)6480464CTDAflatoxin B1 affects the methylation of KCNMA1 intronPMID:30157460
Kcnma1decreases expressionISOKCNMA1 (Homo sapiens)6480464CTDAflatoxin B1 results in decreased expression of KCNMA1 mRNAPMID:31555880 PMID:32234424 PMID:35690182
Kcnma1decreases methylationISOKCNMA1 (Homo sapiens)6480464CTDAflatoxin B1 results in decreased methylation of KCNMA1 exonPMID:30157460
Kcnma1increases expressionISOKcnma1 (Mus musculus)6480464CTDAflatoxin B1 results in increased expression of KCNMA1 mRNAPMID:19770486
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