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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619569
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCC2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCC2affects expressionEXP 6480464CTDAflatoxin B1 affects the expression of ABCC2 proteinPMID:20106945
ABCC2decreases methylationEXP 6480464CTDAflatoxin B1 results in decreased methylation of ABCC2 genePMID:27153756
ABCC2increases expressionEXP 6480464CTDAflatoxin B1 results in increased expression of ABCC2 mRNA; Aflatoxin B1 results in increased expression of ABCC2 proteinPMID:23402939
ABCC2multiple interactionsEXP 6480464CTD[Aflatoxin B1 co-treated with finrozole] results in decreased expression of ABCC2 protein; [Aflatoxin B1 co-treated with finrozole] results in increased expression of ABCC2 protein; finrozole inhibits the reaction [Aflatoxin B1 results in increased expression of ABCC2 mRNA]PMID:23402939
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