Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3959
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vdr
Name: vitamin D receptor
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vdrincreases expressionEXP 6480464CTDAflatoxin B1 results in increased expression of VDR mRNAPMID:23630614 PMID:25378103
Vdraffects response to substanceISOVDR (Homo sapiens)6480464CTDVDR polymorphism affects the susceptibility to Aflatoxin B1PMID:25483621
Vdrdecreases expressionISOVDR (Homo sapiens)6480464CTDAflatoxin B1 results in decreased expression of VDR mRNA; Aflatoxin B1 results in decreased expression of VDR proteinPMID:25483621 PMID:36066700
Vdrincreases expressionISOVDR (Homo sapiens)6480464CTDAflatoxin B1 results in increased expression of VDR mRNAPMID:22100608 PMID:32234424
Vdrmultiple interactionsISOVDR (Homo sapiens)6480464CTDAflatoxin B1 inhibits the reaction [Cholecalciferol affects the localization of VDR protein]; Aflatoxin B1 inhibits the reaction [Cholecalciferol results in increased expression of VDR mRNA]; Aflatoxin B1 inhibits the reaction [Cholecalciferol results in increased expression of VDR protein]; Aflatoxin B1 inhibits the reaction [RARA protein binds to VDR enhancer]; Aflatoxin B1 inhibits the reaction [RXRA protein binds to VDR enhancer]; Aflatoxin B1 inhibits the reaction [RXRA protein binds to VDR promoter]PMID:36066700
Go Back to source page   Continue to Ontology report