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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2869
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1r
Name: insulin-like growth factor 1 receptor
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1rdecreases expressionEXP 6480464CTDAflatoxin B1 results in decreased expression of IGF1R protein modified formPMID:24373827
Igf1rincreases expressionISOIGF1R (Homo sapiens)6480464CTDAflatoxin B1 results in increased expression of IGF1R mRNA; Aflatoxin B1 results in increased expression of IGF1R proteinPMID:20036727
Igf1rincreases methylationISOIGF1R (Homo sapiens)6480464CTDAflatoxin B1 results in increased methylation of IGF1R intronPMID:30157460
Igf1rmultiple interactionsISOIGF1R (Homo sapiens)6480464CTDAflatoxin B1 results in increased expression of and results in increased phosphorylation of IGF1R proteinPMID:20036727
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