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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2690
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1increases expressionEXP 6480464CTDAflatoxin B1 results in increased expression of GJA1 mRNAPMID:23630614 PMID:33354967
Gja1affects expressionISOGJA1 (Homo sapiens)6480464CTDAflatoxin B1 affects the expression of GJA1 proteinPMID:20106945
Gja1decreases expressionISOGja1 (Mus musculus)6480464CTDAflatoxin B1 results in decreased expression of GJA1 proteinPMID:33421461
Gja1increases methylationISOGJA1 (Homo sapiens)6480464CTDAflatoxin B1 results in increased methylation of GJA1 gene; Aflatoxin B1 results in increased methylation of GJA1 intronPMID:27153756 PMID:30157460
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