GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ephx1 | increases activity | EXP | | 152998935 | RGD | aflatoxin increases Ephx1 enzyme activity in rat liver microsomes | | Ephx1 | increases expression | EXP | | 6480464 | CTD | Aflatoxin B1 results in increased expression of EPHX1 mRNA | PMID:14600272 PMID:15890375 PMID:22484513 PMID:23630614 PMID:25378103 PMID:33354967 | Ephx1 | affects response to substance | ISO | Ephx1 (Mus musculus) | 6480464 | CTD | EPHX1 gene SNP affects the susceptibility to Aflatoxin B1 | PMID:12907637 | Ephx1 | decreases expression | ISO | EPHX1 (Homo sapiens) | 6480464 | CTD | Aflatoxin B1 results in decreased expression of EPHX1 mRNA | PMID:27153756 | Ephx1 | decreases methylation | ISO | EPHX1 (Homo sapiens) | 6480464 | CTD | Aflatoxin B1 results in decreased methylation of EPHX1 gene | PMID:27153756 | Ephx1 | increases response to substance | ISO | EPHX1 (Homo sapiens) | 6480464 | CTD | EPHX1 gene mutant form results in increased susceptibility to Aflatoxin B1 | PMID:7892276 | |
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