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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2158
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arsb
Name: arylsulfatase B
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDAflatoxin B1 results in increased expression of ARSB mRNA

PMID:22484513
decreases expressionISORGD:101936480464CTDAflatoxin B1 results in decreased expression of ARSB mRNA

PMID:19770486
decreases methylationISORGD:7373706480464CTDAflatoxin B1 results in decreased methylation of ARSB gene

PMID:27153756
increases methylationISORGD:7373706480464CTDAflatoxin B1 results in increased methylation of ARSB intron

PMID:30157460
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.