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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2100
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alpl
Name: alkaline phosphatase, biomineralization associated
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alplaffects expressionISOALPL (Homo sapiens)6480464CTDAflatoxin B1 affects the expression of ALPL proteinPMID:20106945
Alpldecreases methylationISOALPL (Homo sapiens)6480464CTDAflatoxin B1 results in decreased methylation of ALPL intronPMID:30157460
Alplincreases secretionISOAlpl (Mus musculus)6480464CTDAflatoxin B1 results in increased secretion of ALPL proteinPMID:37030333
Alplmultiple interactionsISOAlpl (Mus musculus)6480464CTDfexaramine inhibits the reaction [Aflatoxin B1 results in increased secretion of ALPL protein]PMID:37030333
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