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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2004
Species: Rattus norvegicus
RGD Object: Gene
Symbol: A2m
Name: alpha-2-macroglobulin
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
A2mincreases expressionEXP 6480464CTDAflatoxin B1 results in increased expression of A2M mRNAPMID:25378103
A2mdecreases expressionISOA2m (Mus musculus)6480464CTDAflatoxin B1 results in decreased expression of A2M mRNAPMID:19770486
A2mdecreases expressionISOA2M (Homo sapiens)6480464CTDAflatoxin B1 results in decreased expression of A2M mRNAPMID:27153756
A2mdecreases methylationISOA2M (Homo sapiens)6480464CTDAflatoxin B1 results in decreased methylation of A2M genePMID:27153756
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