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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308710
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Crim1
Name: cysteine rich transmembrane BMP regulator 1
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13186426480464CTDAflatoxin B1 results in decreased expression of CRIM1 mRNA

PMID:19770486
decreases methylationISORGD:13186416480464CTDAflatoxin B1 results in decreased methylation of CRIM1 exon, Aflatoxin B1 results in decreased methylation of CRIM1 gene

PMID:27153756, PMID:30157460
increases expressionISORGD:13186416480464CTDAflatoxin B1 results in increased expression of CRIM1 mRNA

PMID:27153756
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.