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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306168
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Inpp5a
Name: inositol polyphosphate-5-phosphatase A
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Inpp5aaffects expressionISOINPP5A (Homo sapiens)6480464CTDAflatoxin B1 affects the expression of INPP5A proteinPMID:20106945
Inpp5adecreases expressionISOINPP5A (Homo sapiens)6480464CTDAflatoxin B1 results in decreased expression of INPP5A mRNAPMID:21641981
Inpp5aincreases methylationISOINPP5A (Homo sapiens)6480464CTDAflatoxin B1 results in increased methylation of INPP5A gene; Aflatoxin B1 results in increased methylation of INPP5A intronPMID:27153756 PMID:30157460
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