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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10940
Species: Mus musculus
RGD Object: Gene
Symbol: Myc
Name: myelocytomatosis oncogene
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mycdecreases expressionEXP 6480464CTDAflatoxin B1 results in decreased expression of MYC mRNAPMID:19770486
Mycaffects expressionISOMYC (Homo sapiens)6480464CTDAflatoxin B1 affects the expression of MYC proteinPMID:20106945
Mycincreases expressionISOMyc (Rattus norvegicus)6480464CTDAflatoxin B1 results in increased expression of MYC mRNAPMID:15890375 PMID:25378103
Mycincreases expressionISOMYC (Homo sapiens)6480464CTDAflatoxin B1 results in increased expression of MYC mRNAPMID:27153756
Mycmultiple interactionsISOMyc (Rattus norvegicus)6480464CTD[Aflatoxin B1 co-treated with Ethanol] results in increased expression of MYC mRNA; Sildenafil Citrate inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of MYC mRNA]; Tadalafil inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of MYC mRNA]PMID:35608386
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