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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10065
Species: Homo sapiens
RGD Object: Gene
Symbol: ACLY
Name: ATP citrate lyase
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACLYdecreases methylationEXP 6480464CTDAflatoxin B1 results in decreased methylation of ACLY intronPMID:30157460
ACLYincreases methylationEXP 6480464CTDAflatoxin B1 results in increased methylation of ACLY exonPMID:30157460
ACLYdecreases expressionISOAcly (Mus musculus)6480464CTDAflatoxin B1 results in decreased expression of ACLY mRNAPMID:19770486
ACLYdecreases expressionISOAcly (Rattus norvegicus)6480464CTDAflatoxin B1 results in decreased expression of ACLY mRNAPMID:23385219
ACLYmultiple interactionsISOAcly (Rattus norvegicus)6480464CTD[sulforaphane co-treated with Aflatoxin B1] affects the expression of ACLY mRNAPMID:25450479
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