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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733693
Species: Homo sapiens
RGD Object: Gene
Symbol: AKR7A3
Name: aldo-keto reductase family 7 member A3
Acc ID: CHEBI:24814
Term: indole-3-methanol
Definition: An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
Chemical ID: MESH:C016517
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKR7A3affects expressionISOAkr7a3 (Rattus norvegicus)6480464CTDindole-3-carbinol affects the expression of AKR7A3 mRNAPMID:21396975
AKR7A3increases activityISOAkr7a3 (Rattus norvegicus)6480464CTDindole-3-carbinol results in increased activity of AKR7A3 proteinPMID:9328168
AKR7A3multiple interactionsISOAkr7a3 (Rattus norvegicus)6480464CTD[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNAPMID:22129741
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