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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352399
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCC4
Name: ATP binding cassette subfamily C member 4 (PEL blood group)
Acc ID: CHEBI:2469
Term: adefovir
Definition: A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection.
Chemical ID: MESH:C053001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCC4affects abundanceEXP 6480464CTDABCC4 protein affects the abundance of adefovirPMID:18364470
ABCC4increases exportEXP 6480464CTDABCC4 protein results in increased export of adefovirPMID:18364470
ABCC4decreases expressionISOAbcc4 (Rattus norvegicus)6480464CTDadefovir results in decreased expression of ABCC4 proteinPMID:35114312
ABCC4multiple interactionsISOAbcc4 (Rattus norvegicus)6480464CTD[adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of ABCC4 protein; [adefovir co-treated with Probenecid co-treated with Valsartan] affects the expression of ABCC4 protein; [adefovir co-treated with Probenecid] results in decreased expression of ABCC4 proteinPMID:35114312
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