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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10289
Species: Mus musculus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:2423
Term: acetylleucyl-leucyl-norleucinal
Definition: A tripeptide composed of N-acetylleucyl, leucyl and norleucinal residues joined in sequence.
Chemical ID: MESH:C063261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityEXP 6480464CTDacetylleucyl-leucyl-norleucinal results in increased activity of CASP3 proteinPMID:15618349
Casp3multiple interactionsEXP 6480464CTDacetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]PMID:27481217 PMID:29111403
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