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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737517
Species: Homo sapiens
RGD Object: Gene
Symbol: STAT3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:23995
Term: N-ethyl-N-nitrosourea
Definition: A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.
Chemical ID: MESH:D005038
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
STAT3decreases phosphorylationISOStat3 (Mus musculus)6480464CTDEthylnitrosourea results in decreased phosphorylation of STAT3 proteinPMID:27725143
STAT3increases mutagenesisISOStat3 (Mus musculus)6480464CTDEthylnitrosourea results in increased mutagenesis of STAT3 mRNAPMID:27776689
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