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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1615538
Species: Mus musculus
RGD Object: Gene
Symbol: Cd59b
Name: CD59b antigen
Acc ID: CHEBI:23995
Term: N-ethyl-N-nitrosourea
Definition: A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.
Chemical ID: MESH:D005038
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd59bdecreases lipidationISOCd59b (Rattus norvegicus)6480464CTDEthylnitrosourea results in decreased lipidation of CD59 proteinPMID:27931811
Cd59bincreases mutagenesisISOCD59 (Homo sapiens)6480464CTDEthylnitrosourea results in increased mutagenesis of CD59 proteinPMID:17045307
Cd59bmultiple interactionsISOCd59b (Rattus norvegicus)6480464CTD[Ethylnitrosourea results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein; [Ethylnitrosourea results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 proteinPMID:19965957 PMID:20202993
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