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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350859
Species: Homo sapiens
RGD Object: Gene
Symbol: KRAS
Name: KRAS proto-oncogene, GTPase
Acc ID: CHEBI:23995
Term: N-ethyl-N-nitrosourea
Definition: A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.
Chemical ID: MESH:D005038
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KRASincreases mutagenesisISOKras (Mus musculus)6480464CTDEthylnitrosourea results in increased mutagenesis of KRAS genePMID:15790496
KRASmultiple interactionsISOKras (Mus musculus)6480464CTDEthylnitrosourea promotes the reaction [GATA6 protein binds to KRAS exon]; Ethylnitrosourea promotes the reaction [NFYA protein binds to KRAS exon]PMID:16271038
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