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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619570
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK3
Name: mitogen-activated protein kinase 3
Acc ID: CHEBI:23924
Term: enzyme inhibitor
Definition: A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Chemical ID: MESH:D004791
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK3decreases phosphorylationEXP 6480464CTDEnzyme Inhibitors results in decreased phosphorylation of MAPK3 proteinPMID:25825487
MAPK3multiple interactionsEXP 6480464CTD[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MAPK3 proteinPMID:23301498
MAPK3multiple interactionsISOMapk3 (Mus musculus)6480464CTDEnzyme Inhibitors inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]PMID:25825487
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