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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736782
Species: Homo sapiens
RGD Object: Gene
Symbol: CP
Name: ceruloplasmin
Acc ID: CHEBI:23414
Term: copper(II) sulfate
Definition: A metal sulfate compound having copper(2+) as the metal ion.
Chemical ID: MESH:D019327
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CPdecreases expressionEXP 6480464CTDCopper Sulfate results in decreased expression of CP mRNAPMID:19549813
CPmultiple interactionsEXP 6480464CTD[Copper Sulfate co-treated with CP protein] results in increased expression of CCS mRNA; [Copper Sulfate co-treated with CP protein] results in increased expression of SOD1 mRNAPMID:17683925
CPincreases activityISOCp (Rattus norvegicus)6480464CTDCopper Sulfate results in increased activity of CP proteinPMID:12899943 PMID:23298529
CPincreases expressionISOCp (Rattus norvegicus)6480464CTDCopper Sulfate results in increased expression of CP mRNAPMID:23298529
CPmultiple interactionsISOCp (Rattus norvegicus)6480464CTD[Copper Sulfate co-treated with Quinolinic Acid] results in increased activity of CP protein; Copper Sulfate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of CP protein]PMID:12899943 PMID:23298529
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