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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:23414
Term: copper(II) sulfate
Definition: A metal sulfate compound having copper(2+) as the metal ion.
Chemical ID: MESH:D019327
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxmultiple interactionsEXP 6480464CTD[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA; [Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX protein; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA]; Deferoxamine inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA]; Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX protein]PMID:32881150 PMID:34577062
Baxincreases expressionISOBax (Mus musculus)6480464CTDCopper Sulfate results in increased expression of BAX mRNAPMID:25216733
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA; [Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX proteinPMID:31491480
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