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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1617608
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl15
Name: C-X-C motif chemokine ligand 15
Acc ID: CHEBI:23414
Term: copper(II) sulfate
Definition: A metal sulfate compound having copper(2+) as the metal ion.
Chemical ID: MESH:D019327
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl15increases expressionISOCXCL8 (Homo sapiens)6480464CTDCopper Sulfate results in increased expression of CXCL8 mRNA; Copper Sulfate results in increased expression of CXCL8 proteinPMID:19549813 PMID:26456670 PMID:33839236
Cxcl15increases secretionISOCXCL8 (Homo sapiens)6480464CTDCopper Sulfate results in increased secretion of CXCL8 proteinPMID:16099135 PMID:23692033
Cxcl15multiple interactionsISOCXCL8 (Homo sapiens)6480464CTDCopper Sulfate promotes the reaction [Homocysteine results in increased expression of CXCL8 mRNA]; TLR4 protein inhibits the reaction [Copper Sulfate results in increased secretion of CXCL8 protein]PMID:12964812 PMID:23692033
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