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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11481
Species: Mus musculus
RGD Object: Gene
Symbol: Vcam1
Name: vascular cell adhesion molecule 1
Acc ID: CHEBI:23414
Term: copper(II) sulfate
Definition: A metal sulfate compound having copper(2+) as the metal ion.
Chemical ID: MESH:D019327
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vcam1decreases expressionEXP 6480464CTDCopper Sulfate results in decreased expression of VCAM1 mRNAPMID:18579281
Vcam1increases expressionISOVcam1 (Rattus norvegicus)6480464CTDCopper Sulfate results in increased expression of VCAM1 proteinPMID:30431687
Vcam1increases expressionISOVCAM1 (Homo sapiens)6480464CTDCopper Sulfate results in increased expression of VCAM1 mRNA; Copper Sulfate results in increased expression of VCAM1 proteinPMID:24225134
Vcam1multiple interactionsISOVcam1 (Rattus norvegicus)6480464CTDCurcumin analog inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein]; Deferoxamine inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein]PMID:30431687
Vcam1multiple interactionsISOVCAM1 (Homo sapiens)6480464CTDtetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 mRNA]; tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein]PMID:24225134
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