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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10147
Species: Mus musculus
RGD Object: Gene
Symbol: Alox5
Name: arachidonate 5-lipoxygenase
Acc ID: CHEBI:2340
Term: docebenone
Definition: A member of the class of benzoquinones that is p-benzoquinone in which the hydrogens are substituted by three methyl groups and a 12-hydroxydodeca-5,10-diyn-1-yl group.
Chemical ID: MESH:C036837
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alox5decreases activityEXP 6480464CTD2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX5 proteinPMID:25432964 PMID:7812673
Alox5decreases activityISOAlox5 (Rattus norvegicus)6480464CTD2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX5 proteinPMID:2724698
Alox5decreases activityISOALOX5 (Homo sapiens)6480464CTD2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX5 proteinPMID:2724698
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