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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732909
Species: Homo sapiens
RGD Object: Gene
Symbol: AKT1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKT1decreases phosphorylationEXP 6480464CTDCadmium results in decreased phosphorylation of AKT1 proteinPMID:26187450 PMID:32976933
AKT1increases phosphorylationEXP 6480464CTDCadmium results in increased phosphorylation of AKT1 proteinPMID:14499349 PMID:17125913 PMID:22884995 PMID:26514923
AKT1multiple interactionsEXP 6480464CTD[[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with fenvalerate] results in increased phosphorylation of AKT1 protein; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; CAT protein inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; diphenyleneiodonium inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; Fulvestrant inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; SOD1 protein inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; SOD2 protein inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]PMID:17125913 PMID:22884995 PMID:26514923 PMID:28949029
AKT1decreases expressionISOAkt1 (Mus musculus)6480464CTDCadmium results in decreased expression of AKT1 mRNAPMID:26187450
AKT1decreases phosphorylationISOAkt1 (Mus musculus)6480464CTDCadmium results in decreased phosphorylation of AKT1 proteinPMID:37148155
AKT1increases activityISOAkt1 (Rattus norvegicus)6480464CTDCadmium results in increased activity of AKT1 proteinPMID:18573614
AKT1increases phosphorylationISOAkt1 (Rattus norvegicus)6480464CTDCadmium results in increased phosphorylation of AKT1 proteinPMID:27658547
AKT1increases phosphorylationISOAkt1 (Mus musculus)6480464CTDCadmium results in increased phosphorylation of AKT1 proteinPMID:24449419
AKT1multiple interactionsISOAkt1 (Rattus norvegicus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased phosphorylation of AKT1 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of AKT1 protein; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; CASR protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of AKT1 protein]; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of AKT1 protein]; Triiodothyronine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased phosphorylation of AKT1 protein]PMID:27658547 PMID:32599263 PMID:34767868 PMID:36868496
AKT1multiple interactionsISOAkt1 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of AKT1 mRNA; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; Buthionine Sulfoximine promotes the reaction [Cadmium results in increased phosphorylation of AKT1 protein]PMID:24449419 PMID:33259630
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