GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | AKT1 | decreases phosphorylation | EXP | | 6480464 | CTD | Cadmium results in decreased phosphorylation of AKT1 protein | PMID:26187450 PMID:32976933 | AKT1 | increases phosphorylation | EXP | | 6480464 | CTD | Cadmium results in increased phosphorylation of AKT1 protein | PMID:14499349 PMID:17125913 PMID:22884995 PMID:26514923 | AKT1 | multiple interactions | EXP | | 6480464 | CTD | [[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with fenvalerate] results in increased phosphorylation of AKT1 protein; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; CAT protein inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; diphenyleneiodonium inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; Fulvestrant inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; SOD1 protein inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; SOD2 protein inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein] | PMID:17125913 PMID:22884995 PMID:26514923 PMID:28949029 | AKT1 | decreases expression | ISO | Akt1 (Mus musculus) | 6480464 | CTD | Cadmium results in decreased expression of AKT1 mRNA | PMID:26187450 | AKT1 | decreases phosphorylation | ISO | Akt1 (Mus musculus) | 6480464 | CTD | Cadmium results in decreased phosphorylation of AKT1 protein | PMID:37148155 | AKT1 | increases activity | ISO | Akt1 (Rattus norvegicus) | 6480464 | CTD | Cadmium results in increased activity of AKT1 protein | PMID:18573614 | AKT1 | increases phosphorylation | ISO | Akt1 (Rattus norvegicus) | 6480464 | CTD | Cadmium results in increased phosphorylation of AKT1 protein | PMID:27658547 | AKT1 | increases phosphorylation | ISO | Akt1 (Mus musculus) | 6480464 | CTD | Cadmium results in increased phosphorylation of AKT1 protein | PMID:24449419 | AKT1 | multiple interactions | ISO | Akt1 (Rattus norvegicus) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased phosphorylation of AKT1 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of AKT1 protein; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; CASR protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of AKT1 protein]; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of AKT1 protein]; Triiodothyronine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased phosphorylation of AKT1 protein] | PMID:27658547 PMID:32599263 PMID:34767868 PMID:36868496 | AKT1 | multiple interactions | ISO | Akt1 (Mus musculus) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of AKT1 mRNA; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; Buthionine Sulfoximine promotes the reaction [Cadmium results in increased phosphorylation of AKT1 protein] | PMID:24449419 PMID:33259630 | |
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