GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk8 | increases phosphorylation | EXP | | 6480464 | CTD | Cadmium results in increased phosphorylation of MAPK8 protein | PMID:15212812 PMID:15254339 | Mapk8 | multiple interactions | EXP | | 6480464 | CTD | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of and results in increased activity of MAPK8 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein; [MT1 protein co-treated with MT2 protein] inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein]; Cadmium results in increased phosphorylation of and results in increased activity of MAPK8 protein; Egtazic Acid inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Cadmium results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Silymarin inhibits the reaction [Cadmium results in increased phosphorylation of and results in increased activity of MAPK8 protein]; VDAC2 protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein] | PMID:15254339 PMID:16568437 PMID:16728380 PMID:18506790 PMID:30796935 PMID:31271426 PMID:32199951 PMID:37261864 | Mapk8 | affects response to substance | ISO | Mapk8 (Rattus norvegicus) | 6480464 | CTD | MAPK8 protein affects the susceptibility to Cadmium | PMID:16516943 | Mapk8 | decreases response to substance | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | MAPK8 mutant form results in decreased susceptibility to Cadmium | PMID:10874022 | Mapk8 | increases phosphorylation | ISO | Mapk8 (Rattus norvegicus) | 6480464 | CTD | Cadmium results in increased phosphorylation of MAPK8 protein | PMID:18463101 | Mapk8 | increases phosphorylation | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | Cadmium results in increased phosphorylation of MAPK8 protein | PMID:26187450 PMID:26514923 | Mapk8 | multiple interactions | ISO | Mapk8 (Rattus norvegicus) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein; Cadmium results in increased phosphorylation of and results in increased activity of MAPK8 protein; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein] | PMID:16568437 PMID:34510229 PMID:34767868 | Mapk8 | multiple interactions | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]; diphenyleneiodonium inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]; fenvalerate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein]; RTKI cpd inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]; Selenium inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein] | PMID:26187450 PMID:26514923 PMID:28949029 PMID:34510229 | | ||||||||||||||||||||||
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