GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sqstm1 | decreases expression | EXP | | 6480464 | CTD | Cadmium results in decreased expression of SQSTM1 protein | PMID:27658547 PMID:32693121 | Sqstm1 | increases expression | EXP | | 6480464 | CTD | Cadmium results in increased expression of SQSTM1 protein | PMID:32347499 | Sqstm1 | multiple interactions | EXP | | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SQSTM1 protein; ATG5 protein affects the reaction [Cadmium results in decreased expression of SQSTM1 protein]; bafilomycin A inhibits the reaction [Cadmium results in decreased expression of SQSTM1 protein]; brusatol inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Cadmium results in decreased expression of SQSTM1 protein]; MAP3K7 protein affects the reaction [Cadmium results in decreased expression of SQSTM1 protein]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SQSTM1 protein]; Quercetin inhibits the reaction [Cadmium results in increased expression of SQSTM1 protein] | PMID:27658547 PMID:32347499 PMID:32693121 PMID:34695510 | Sqstm1 | decreases expression | ISO | Sqstm1 (Mus musculus) | 6480464 | CTD | Cadmium results in decreased expression of SQSTM1 protein | PMID:37148155 | Sqstm1 | increases expression | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | Cadmium results in increased expression of SQSTM1 mRNA | PMID:21120746 | Sqstm1 | increases expression | ISO | Sqstm1 (Mus musculus) | 6480464 | CTD | Cadmium results in increased expression of SQSTM1 mRNA | PMID:24067728 | Sqstm1 | multiple interactions | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | 3-methyladenine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SQSTM1 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SQSTM1 protein; ATG5 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SQSTM1 protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SQSTM1 protein] | PMID:31319114 PMID:34481905 PMID:36336208 | Sqstm1 | multiple interactions | ISO | Sqstm1 (Mus musculus) | 6480464 | CTD | 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SQSTM1 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SQSTM1 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SQSTM1 protein; [Sirolimus co-treated with Cadmium] results in decreased expression of SQSTM1 protein; PINK1 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SQSTM1 protein] | PMID:31862506 PMID:34952138 PMID:36336208 PMID:37022104 PMID:37148155 | | ||||||||||||||||||||||
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