GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ddit3 | increases expression | EXP | | 6480464 | CTD | Cadmium results in increased expression of DDIT3 mRNA; Cadmium results in increased expression of DDIT3 protein | PMID:15010501 PMID:19442655 PMID:29111403 | Ddit3 | multiple interactions | EXP | | 6480464 | CTD | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DDIT3 protein; [Egtazic Acid co-treated with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid] inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]; Egtazic Acid inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]; O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Cadmium results in increased expression of DDIT3 mRNA] | PMID:15010501 PMID:19442655 PMID:29111403 PMID:37261864 | Ddit3 | increases expression | ISO | Ddit3 (Rattus norvegicus) | 6480464 | CTD | Cadmium results in increased expression of DDIT3 protein | PMID:27658547 | Ddit3 | increases expression | ISO | DDIT3 (Homo sapiens) | 6480464 | CTD | Cadmium results in increased expression of DDIT3; Cadmium results in increased expression of DDIT3 mRNA; Cadmium results in increased expression of DDIT3 protein | PMID:20600546 PMID:21120746 PMID:21694771 PMID:23339468 PMID:33559965 | Ddit3 | multiple interactions | ISO | Ddit3 (Rattus norvegicus) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]; ATG5 protein affects the reaction [Cadmium results in increased expression of DDIT3 protein]; bafilomycin A promotes the reaction [Cadmium results in increased expression of DDIT3 protein]; Chloroquine promotes the reaction [Cadmium results in increased expression of DDIT3 protein]; GSK3A protein affects the reaction [Cadmium results in increased expression of DDIT3 protein]; GSK3B protein affects the reaction [Cadmium results in increased expression of DDIT3 protein]; Lithium Chloride promotes the reaction [Cadmium results in increased expression of DDIT3 protein]; rottlerin inhibits the reaction [Cadmium results in increased expression of DDIT3 protein] | PMID:27658547 | Ddit3 | multiple interactions | ISO | DDIT3 (Homo sapiens) | 6480464 | CTD | 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DDIT3 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DDIT3 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DDIT3 protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of DDIT3] | PMID:23339468 PMID:31738976 PMID:37300854 | | ||||||||||||||||||||||
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